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Atrial fibrillation is the most common form of cardiac arrhythmia and is associated with an increased risk of stroke, heart failure and mortality. Immunosenescence describes the aging of the immune system. This process is progressive and characterized by both an increase in pro-inflammatory cytokines and a decrease in (adaptive) immunity. The dynamic balance of pro- and anti-inflammatory cytokines is increasingly disturbed during the aging process (Inflammaging). It is known that this age-related chronic inflammatory process also plays an important role in the development of atrial fibrillation. Whether immunosenescence that occurs in old age is more common in patients with atrial fibrillation has not yet been investigated.