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Das Bild zeigt eine Ärztin am Schreibtisch, die einem Patienten ein Röntgenbild erklärt.

Intrinsic sex differences in endothelial barrier function

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Intrinsic sex differences in endothelial barrier function and monocyte transendothelial migration in cell culture models of atherosclerosis - Project profile


Cardiovascular diseases (CVD) are the major cause of death worldwide. Women have a better cardioprotection and less inflammation compared to men. However, increased inflammation after menopausal hormone changes coincides with a higher prevalence of CVD and impaired cardiac function. Inflammation and endothelial dysfunction are key factors in CVD and atherosclerosis. Monocyte transmigration represents a pivotal step in the initiation of the inflammatory response in the damaged tissue. Increasing evidence suggests that dysregulated monocyte transendothelial migration promotes an excessive inflammatory response and myocardial injury.

Aims and Procedure

This project aims to fill knowledge gaps on sex-dependent modulation of endothelial barrier function and monocyte transmigration using unique sex-specific cell culture models to delay early pathomechanisms in atherosclerosis without the influence of hormones.

Project duration

07/2022 – 12/2023

Project members

Rachel Presser

MD doctoral student

Further project information