Intrinsic sex differences in endothelial barrier function
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Motivation
Cardiovascular diseases (CVD) are the major cause of death worldwide. Women have a better cardioprotection and less inflammation compared to men. However, increased inflammation after menopausal hormone changes coincides with a higher prevalence of CVD and impaired cardiac function. Inflammation and endothelial dysfunction are key factors in CVD and atherosclerosis. Monocyte transmigration represents a pivotal step in the initiation of the inflammatory response in the damaged tissue. Increasing evidence suggests that dysregulated monocyte transendothelial migration promotes an excessive inflammatory response and myocardial injury.
