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Das Bild zeigt eine Ärztin am Schreibtisch, die einem Patienten ein Röntgenbild erklärt.

Intrinsic sex differences

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Intrinsic sex differences in mitochondrial function in an atherosclerosis model - Project profile


In a previous study, we found sex differences in inflammation and in mitochondrial function, leading to decreased mitochondrial functionality in the heart of healthy men compared to healthy women. In addition, we investigated sex differences in mitochondrial fission and fusion in female and male human umbilical endothelial cells (HUVEC). Treatment of HUVEC with the pro-inflammatory mediator TNF-α significantly increased mitochondrial granularity in men rather than women, which can be explained by an increased pro-inflammatory environment in men.

Aims and Procedure

The project aims to close the missing knowledge gaps about intrinsic sex differences in mitochondrial dysfunction of the endothelial barrier using an atherosclerosis cell culture model. The overall aim of our study is to identify approaches of mitochondrial function and biogenesis in human endothelial cells and monocytes from male and female donors under standard, beneficial (antioxidants) and pathological conditions (induced inflammation).)

Project duration

04/2021 – 12/2023

Project members

Julia Freitag

Bachelor student

Standard-Porträt "Person, neutral"
Natalia Haritonow

Medical-technical laboratory assistant

Further project information