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Das Bild zeigt eine Ärztin am Schreibtisch, die einem Patienten ein Röntgenbild erklärt.

Aging-related endothelial dysfunction

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Aging-related endothelial dysfunction - Project profile


Aging is a major risk factor for the development of several cardiovascular diseases. Some cardiovascular diseases such as atherosclerosis or hypertension are accompanied by a decreased endothelial function. Age-related endothelial dysfunction affects the balance between vasodilator and vasoconstriction substances in the endothelium. In addition, oxidative stress and inflammation seem to be the primary causes of age-related endothelial dysfunction.

Aims and Procedure

The aim of this project is to investigate whether cellular senescence has an impact on inflammatory processes and mitochondrial dysfunction, which may promote endothelial dysfunction. We also aim to examine the influence of intrinsic sex on age-related endothelial dysfunction.

Project duration

07/2020 – 06/2023

Project members

Kristina Zollner

Medicine doctoral student